Carbohydrate-deficient transferrin: a marker of alcohol abuse.
نویسنده
چکیده
Serum carbohydrate-deficient transferrin (CDT) measurement is valuable for the identification of chronic excess alcohol consumption. CDT is increased in serum in approximately 50% of those classed as heavy drinkers and 70-80% of those defined as alcoholics. With abstinence, the serum CDT concentration reverts towards normal within approximately 2 weeks. Specificity for alcohol abuse ranges from 80 to 95% in the general population and from 70 to 80% in liver clinic patients.
منابع مشابه
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chronic alcohol abuse in drivers. Forensic Sci Int;in press. 6. Berkowicz A, Wallerstedt S, Wall K, Denison H. Carbohydrate-deficient transferrin in vitreous humour: a marker of possible withdrawal-related death in alcoholics. Alcohol 2001;36:231–4. 7. Helander A, Eriksson G, Stibler H, Jeppsson J-O. Interference of transferrin isoform types with carbohydrate-deficient transferrin quantificatio...
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During the last 16 years an increasing number of studies have indicated a new diagnostic marker of alcohol abuse, unrelated to any of the conventional markers of alcoholism. This marker, now called carbohydrate-deficient transferrin, consists mainly of one or two isoforms of transferrin that are deficient in their terminal trisaccharides. Such isoforms have so far been detected by methods based...
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Alcohol use and abuse is a major social and economic problem in many societies. Carbohydrate-deficient transferrin (CDT) is a widely used and highly specific biochemical alcohol marker of prolonged alcohol abuse. Increased knowledge about the clinical characteristics of CDT may lead to better possibilities of employing CDT as a biochemical alcohol marker of risky and heavy alcohol consumption a...
متن کاملLaboratory markers of alcohol abuse.
A number of routine laboratory markers provide objective information about alcohol use and abuse. The usefulness of these markers is discussed. One such marker recently developed is serum carbohydrate-deficient transferrin (CDT), which has a greater overall marker potential than other existing tests. The use of CDT in combination with some of the other markers is likely to enhance the detection...
متن کاملInterference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse.
BACKGROUND Isoforms of transferrin interfere with measurement of carbohydrate-deficient transferrin (CDT) as a marker of heavy alcohol consumption. We evaluated the rate of inaccurate CDT results by immunoassays. METHODS We studied 2360 consecutive sera (1614 individuals) submitted for CDT assay without clinical information as well as samples from 1 patient with a congenital disorder of glyco...
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ورودعنوان ژورنال:
- BMJ
دوره 299 6696 شماره
صفحات -
تاریخ انتشار 1989